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Michael O'Neill Selected Research

IBL-302

11/2021Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors.
1/2020Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma.
1/2020Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer.
1/2019Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma.

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Michael O'Neill Research Topics

Disease

4Neuroblastoma
11/2021 - 10/2016
4Neoplasms (Cancer)
11/2021 - 01/2019
3Breast Neoplasms (Breast Cancer)
11/2021 - 09/2010
1Cognitive Dysfunction
11/2023
1Human Influenza (Influenza)
11/2023
1Fistula
01/2023
1Inflammation (Inflammations)
04/2021
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
10/2020
1Alzheimer Disease (Alzheimer's Disease)
10/2016
1Disease Progression
10/2016
1Tauopathies
10/2016
1Head and Neck Neoplasms (Head and Neck Cancer)
10/2011
1Nausea
09/2010
1Parkinson Disease (Parkinson's Disease)
05/2007
1Movement Disorders (Movement Disorder)
05/2007

Drug/Important Bio-Agent (IBA)

5Phosphotransferases (Kinase)IBA
11/2021 - 01/2019
4IBL-302IBA
11/2021 - 01/2019
2Proteins (Proteins, Gene)FDA Link
04/2021 - 10/2020
1N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA
11/2023
1Amyloid (Amyloid Fibrils)IBA
11/2023
1Influenza Vaccines (Influenza Vaccine)FDA Link
11/2023
1Therapeutic UsesIBA
11/2021
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
04/2021
1proto-oncogene proteins pimIBA
04/2021
1Trastuzumab (Herceptin)FDA Link
01/2020
1Lapatinib (GW572016)FDA Link
01/2020
1Cisplatin (Platino)FDA LinkGeneric
01/2019
1N-Myc Proto-Oncogene ProteinIBA
01/2019
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
10/2016
1CaspasesIBA
10/2016
1AntiemeticsIBA
09/2010
1Dopamine (Intropin)FDA LinkGeneric
05/2007

Therapy/Procedure

2Drug Therapy (Chemotherapy)
01/2019 - 09/2010
2Therapeutics
01/2019 - 10/2016
1Central Venous Catheters
01/2023
1Radiotherapy
10/2011
1Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)
10/2011
1Acupressure (Shiatsu)
09/2010